کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8476764 1550847 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration
ترجمه فارسی عنوان
هدف از پاسخ هیپوکسیک در مهندسی بافت استخوانی: تعادل بین عرضه و مصرف برای بهبود بازسازی استخوان
کلمات کلیدی
بازسازی استخوان، مهندسی بافت، سیگنالینگ هیپوکسی آنژیوژنز، بقای سلولی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Bone tissue engineering is a promising therapeutic alternative for bone grafting of large skeletal defects. It generally comprises an ex vivo engineered combination of a carrier structure, stem/progenitor cells and growth factors. However, the success of these regenerative implants largely depends on how well implanted cells will adapt to the hostile and hypoxic host environment they encounter after implantation. In this review, we will discuss how hypoxia signalling may be used to improve bone regeneration in a tissue-engineered construct. First, hypoxia signalling induces angiogenesis which increases the survival of the implanted cells as well as stimulates bone formation. Second, hypoxia signalling has also angiogenesis-independent effects on mesenchymal cells in vitro, offering exciting new possibilities to improve tissue-engineered bone regeneration in vivo. In addition, studies in other fields have shown that benefits of modulating hypoxia signalling include enhanced cell survival, proliferation and differentiation, culminating in a more potent regenerative implant. Finally, the stimulation of endochondral bone formation as a physiological pathway to circumvent the harmful effects of hypoxia will be briefly touched upon. Thus, angiogenic dependent and independent processes may counteract the deleterious hypoxic effects and we will discuss several therapeutic strategies that may be combined to withstand the hypoxia upon implantation and improve bone regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 432, 5 September 2016, Pages 96-105
نویسندگان
, , ,