Calcium-dependent mitochondrial cAMP production enhances aldosterone secretion

- HCO3− activates mitochondrial adenylyl cyclase (sAC) in human adrenocortical cells.
- Angiotensin II causes a mitochondrial [cAMP] rise in a [Ca2+]mito-dependent way.
- cAMP signal is reduced by siRNA for sAC, and enhanced by PDE2-inhibitor.
- Inhibition of sAC attenuates angiotensin II-induced aldosterone secretion.