Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes

- GR ChIP-Seq identified primary targets in GC-treated mouse primary keratinocytes.
- Binding motifs for GR and Klf4 were over represented in GR ChIP-seq peaks.
- GR and Klf4 target Tsc22d3 and Zfp36, regulators of inflammation.
- GR is required for Klf4, Tsc22d3 and Zfp36 induction in terminal differentiation.
- GR negatively regulates Trp63 isoforms in keratinocytes.