Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats

- In vivo blockade of testicular α1-ADRs reduces circulating androgen level.
- α1-ADR blockade abolished stress-induced partial recovery of androgen production.
- α1-ADRs mediate stress-reduced steroidogenic stimulator Nur77 in Leydig cells.
- α1-ADRs mediate stress-increased repressors Dax1 and Arr19 in Leydig cells.
- α1-ADRs on Leydig cell regulate transcription of steroidogenic stimulator Nur77.