TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development

- TGFβ isoforms and both TGFβ receptors are expressed in the developing hypothalamus.
- TGFβ2 regulates both TIEG1 and Trh expressions in a TβRI dependent manner.
- TIEG1 binds to a GC rich sequence on the promoter region to regulate Trh expression.
- TGFβ2, through TIEG1 action, regulates Trh expression within the hypothalamus.
- TIEG1 expression is necessary but not sufficient for the correct hypothalamic Trh expression.