cAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse

► cAMP signaling may affect cell growth, development, and tumor formation in cAMP-sensitive tissues. ► Primary bilateral adrenal hyperplasias are genetically heterogeneous; most have defects in cAMP. ► Tissue-specific pluripotential cells may initiate tumor formation in cAMP-sensitive tissues.