Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells

► CRF, Ucn1, and their corresponding receptors are expressed in mammalian skin. ► CRF and Ucn1 stimulate TRP1 gene transcription via the CRF1 receptor. ► Both CRF- and Ucn1-induced Nurr-1/Nur77 acts via NBREs on the TRP1 promoter. ► CRF and Ucn1 can regulate TRP1 gene expression via Nurr-1/Nur77 production.