GLP-2 receptors in human disease: High expression in gastrointestinal stromal tumors and Crohn's disease

► GLP-2 has been linked to carcinogenesis. ► The GLP-2 analogue teduglutide reduces inflammation in Crohn's disease patients. ► We found GLP-2 receptors in GIST tumor cells and in myenteric nerves in Crohn. ► GLP-2 receptors in GIST may be in vivo targets for radioactive GLP-2 analogs. ► The myenteric GLP-2 receptors may be teduglutide targets in Crohn's disease.