DDX5 is a multifunctional co-activator of steroid hormone receptors

► The DEAD box RNA helicase p68 (DDX5) interacts with the vitamin D receptor (VDR). ► In DDX5 enhances reporter response and transcription of calcitriol target genes. ► Knock-down of DDX5 compensates for these responses. ► DDX5 is a VDR co-activator.