Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

► Intracerebroventricular administration of galanin antagonist sustains insulin resistance. ► Galanin in brain enhances GLUT4 contents in membranes of adipocytes in type 2 diabetes rats. ► Exercise-induced central galanin release promotes GLUT4 trafficking to plasma membranes.