Endocrine prevention and treatment of prostate cancer

► 5-ARIs reduce risk of being diagnosed with prostate cancer but they do not eliminate it. ► Castration remains the frontline treatment for metastatic prostate cancer. ► Neoadjuvant endocrine treatment has its place mainly in the external beam radiotherapy setting. ► IAD is as effective as continuous ADT in non-metastatic, locally advanced prostate cancer. ► The decision regarding the type of androgen deprivation should be made individually.