The epigenome as a target for heritable environmental disruptions of cellular function

► The epigenome is a primary target of environmentally-induced disruption. ► Disruptions of the epigenome result in epimutations. ► Epimutations are typically heritable in somatic cell lineages. ► Epimutations are typically corrected by germline reprogramming. ► Uncorrected epimutations may be transmitted transgenerationally.