Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action

► The pathways of GPCR-mediated eCB release and their mechanisms are reviewed. ► Activation of Gq/11 and Gs proteins can stimulate the endocannabinoid system. ► CB1 receptor inhibition blocks the hypertensive effect of angiotensin II in the PVN. ► 2-AG formation is a general consequence of Gq/11-coupled receptor activation.