کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8477795 1550931 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene structure analysis of kisspeptin-2 (Kiss2) in the Senegalese sole (Solea senegalensis): Characterization of two splice variants of Kiss2, and novel evidence for metabolic regulation of kisspeptin signaling in non-mammalian species
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Gene structure analysis of kisspeptin-2 (Kiss2) in the Senegalese sole (Solea senegalensis): Characterization of two splice variants of Kiss2, and novel evidence for metabolic regulation of kisspeptin signaling in non-mammalian species
چکیده انگلیسی
► We present novel evidence indicating that kisspeptin may link energy balance and reproduction. ► We determined the gene structure of kisspeptin in the Senegalese sole, which has only one paralogous gene, Kiss2. ► We detected two Ss Kiss2 isoforms generated by alternative splicing through intronic retention. ► Ss Kiss2_v1 produces the functional protein, while Ss Kiss2_v2 codes for a non-functional protein. ► Fasting increased hypothalamic mRNA levels of Ss Kiss2_v1 and Ss LH and Ss FSH mRNA the pituitary.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 339, Issues 1–2, 6 June 2011, Pages 14-24
نویسندگان
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