PKC and PTPα participate in Src activation by 1α,25(OH)2 vitamin D3 in C2C12 skeletal muscle cells

► This work provides evidence on the mechanism by which 1α,25(OH)2D3 transmits its signal to Src in C2C12 skeletal muscle cells. We demonstrated that 1α,25(OH)2D3 acts in skeletal muscle upstream on MAPK cascades sequentially activating PKC, PTPα and Src.