کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477985 | 1550936 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endogenously elevated androgens alter the developmental programming of the hypothalamic-pituitary axis in male mice
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کلمات کلیدی
PNDAVPVHPGDPCAndrogen - آندروژنpost natal day - روز تولدdays post-coitum - روز پس از مقاربتArc - قوسtransgenic model - مدل ترانس ژنیکwild-type - نوع وحشیarcuate nucleus - هسته قوسanteroventral periventricular nucleus - هسته پرویه ونتریکولار anteroventralfollicle stimulating hormone - هورمون تحریک کننده فولیکولhypothalamic–pituitary–gonadal - هیپوتالاموس-هیپوفیز-گنادالhuman chorionic gonadotrophin - گنادوتروپین کوریونی انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Transgenic male mice that express human chorionic gonadotropin (hCG) α and β subunits constitutively hypersecrete hCG and produce elevated levels of androgens. The aim of this study was to characterize the hypothalamic-pituitary function of these transgenic (hCGαβ+) males by focusing on FSH regulation. Serum FSH levels and pituitary mRNA expression of Fshb, Lhb, Cga, Gnrhr and Esr1 were reduced, whereas Fst expression was increased in prepubertal hCGαβ+ males as compared with wild-type. In the hypothalamus, Cyp19a1 expression, GnRH concentration and ex-vivo GnRH pulsatility were elevated in prepubertal hCGαβ+ mice, whereas Kiss1 expression was decreased prepubertally and Gad67 expression was elevated neonatally. The effect of androgens on the developmental programming of the hypothalamic-pituitary axis of hCGαβ+ males was evaluated by perinatal and prepubertal antiandrogen (flutamide) administration. Our studies identified a critical window between gestational day 18 and postnatal day 14, during which chronically elevated androgens and/or their locally produced metabolites activate the hypothalamus and concomitantly shut-down the gonadotropin axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 332, Issues 1â2, 30 January 2011, Pages 78-87
Journal: Molecular and Cellular Endocrinology - Volume 332, Issues 1â2, 30 January 2011, Pages 78-87
نویسندگان
Betina Gonzalez, Laura D. Ratner, Noelia P. Di Giorgio, Matti Poutanen, Ilpo T. Huhtaniemi, Ricardo S. Calandra, Victoria A.R. Lux-Lantos, Susana B. Rulli,