کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8478325 1550999 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Constitutively active luteinizing hormone receptors: Consequences of in vivo expression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Constitutively active luteinizing hormone receptors: Consequences of in vivo expression
چکیده انگلیسی
Activating mutations in the luteinizing hormone receptor (LHR) gene are one of the most common mutations found in the gonadotropin receptor genes. Human males with these mutations exhibit precocious puberty while females do not have an obvious phenotype. To better understand the pathophysiology of premature LHR activation, transgenic mice have been generated with an activating mutation in LHR and a genetically engineered ligand-activated LHR. This review will summarize the major findings obtained with these two genetically modified mouse models and briefly discuss the similarities and differences between them and with the human phenotype.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volumes 260–262, 2 January 2007, Pages 294-300
نویسندگان
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