کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478357 | 1551117 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide Aβ-oligomer uptake and the resulting inflammatory response in adult human astrocytes are precluded by an anti-Aβ single chain variable fragment in combination with an apoE mimetic peptide](/preview/png/8478357.png)
چکیده انگلیسی
Proposed mechanism of action of apoE and apoJ mimetic peptides (MP) and a single chain variable fragment of a humanized monoclonal antibody that specifically detects Amyloid-β (Aβ), scFv-h3D6, on Aβ clearance and Aβ-induced inflammation in adult human primary astrocytes. Aβ oligomers induce the release of proinflammatory cytokines IL-6 and MCP-1, which is reduced in the presence of apoE-MP in vitro. At the same time, Aβ oligomer uptake is reduced by apoE-MP, as well as apoJ-MP and, more potently, scFv-h3D6. Because apo-MP do not interfere with the inhibitory effect of scFv-h3D6 on uptake, a combination of the anti-inflammatory apoE-MP and scFv-h3D6 merits further investigation for therapeutic use.120
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 89, June 2018, Pages 49-59
Journal: Molecular and Cellular Neuroscience - Volume 89, June 2018, Pages 49-59
نویسندگان
Laia Montoliu-Gaya, Sandra D. Mulder, Maaike A.C. Herrebout, Johannes C. Baayen, Sandra Villegas, Robert Veerhuis,