کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478530 | 1551138 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nectin-1 spots regulate the branching of olfactory mitral cell dendrites
ترجمه فارسی عنوان
لکه های نکتین-1 رشته شاخه های دندریت های سلول میترال بویایی را تنظیم می کنند
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کلمات کلیدی
لامپ رژ لب، سلول میترال، دندریت، سیناپس متقابل، نکتین-1،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Olfactory mitral cells extend lateral secondary dendrites that contact the lateral secondary and apical primary dendrites of other mitral cells in the external plexiform layer (EPL) of the olfactory bulb. The lateral dendrites further contact granule cell dendrites, forming dendrodendritic reciprocal synapses in the EPL. These dendritic structures are critical for odor information processing, but it remains unknown how they are formed. We recently showed that the immunoglobulin-like cell adhesion molecule nectin-1 constitutes a novel adhesion apparatus at the contacts between mitral cell lateral dendrites, between mitral cell lateral and apical dendrites, and between mitral cell lateral dendrites and granule cell dendritic spine necks in the deep sub-lamina of the EPL of the developing mouse olfactory bulb and named them nectin-1 spots. We investigated here the role of the nectin-1 spots in the formation of dendritic structures in the EPL of the mouse olfactory bulb. We showed that in cultured nectin-1-knockout mitral cells, the number of branching points of mitral cell dendrites was reduced compared to that in the control cells. In the deep sub-lamina of the EPL in the nectin-1-knockout olfactory bulb, the number of branching points of mitral cell lateral dendrites and the number of dendrodendritic reciprocal synapses were reduced compared to those in the control olfactory bulb. These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 68, September 2015, Pages 143-150
Journal: Molecular and Cellular Neuroscience - Volume 68, September 2015, Pages 143-150
نویسندگان
Takeshi Fujiwara, Takahito Inoue, Tomohiko Maruo, Yoshiyuki Rikitake, Nao Ieki, Kenji Mandai, Kazushi Kimura, Tetsuro Kayahara, Shujie Wang, Yu Itoh, Kousyoku Sai, Masahiro Mori, Kensaku Mori, Yoshimi Takai, Akira Mizoguchi,