Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation

► Study on role of cannabinoid CB1 receptors in amphetamine-induced monoamine release. ► CB1 receptor antagonist SR141716A blocked amphetamine-induced dopamine release. ► SR141716A effects were restricted to the nucleus accumbens shell subregion. ► SR141716A effects were selective for dopamine over other monoamines. ► Monoamine- and region-specific role CB1 receptors may subserve effects amphetamine.