Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole

► We study the effects of grape juice treatments in rats against PTZ-induced seizure. ► The polyphenolic profile of organic and conventional grape juice is also evaluated. ► Both juices show neuroprotective effect against PTZ-induced oxidative damage in rats. ► This effect is possible due to high polyphenol and ascorbic acid content in juices. ► Grape juices may be used to develop new therapeutic strategies against epilepsy.