کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8479621 1551344 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear retention of mRNAs - quality control, gene regulation and human disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Nuclear retention of mRNAs - quality control, gene regulation and human disease
چکیده انگلیسی
Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously underappreciated layer of gene regulation, which enables the cell to rapidly respond to stress, viral infection, differentiation cues or changing environmental conditions. Focusing on mammalian cells, we discuss recent insights into the mechanisms and functions of nuclear retention, describe retention-promoting features in protein-coding transcripts and propose mechanisms for their regulated release into the cytoplasm. Moreover, we discuss examples of how aberrant nuclear retention of mRNAs may lead to human diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 79, July 2018, Pages 131-142
نویسندگان
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