کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480284 1551377 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calcium signaling in membrane repair
ترجمه فارسی عنوان
سیگنالینگ کلسیم در تعمیر غشا
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM) disruptions occur. Models of PM repair mechanisms include the “lipid-patch”, “endocytic removal”, and “macro-vesicle shedding” models, all of which postulate a dependence on local increases in intracellular Ca2+ at injury sites. Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca2+ may regulate multiple steps of the repair process. Although earlier studies focused exclusively on external Ca2+, recent studies suggest that Ca2+ release from intracellular stores may also be important for PM resealing. Hence, depending on injury size and the type of injury, multiple sources of Ca2+ may be recruited to trigger and orchestrate repair processes. In this review, we discuss the mechanisms by which the resealing process is promoted by vesicular Ca2+ channels and Ca2+ sensors that accumulate at damage sites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 45, September 2015, Pages 24-31
نویسندگان
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