کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480563 | 1551387 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Information theory and signal transduction systems: From molecular information processing to network inference
ترجمه فارسی عنوان
تئوری اطلاعات و سیستم انتقال سیگنال: از پردازش اطلاعات مولکولی تا استنتاج شبکه
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کلمات کلیدی
پردازش سیگنال، اطلاعات متقابل، سر و صدا، استنتاج شبکه، طراحی تجربی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Sensing and responding to the environment are two essential functions that all biological organisms need to master for survival and successful reproduction. Developmental processes are marshalled by a diverse set of signalling and control systems, ranging from systems with simple chemical inputs and outputs to complex molecular and cellular networks with non-linear dynamics. Information theory provides a powerful and convenient framework in which such systems can be studied; but it also provides the means to reconstruct the structure and dynamics of molecular interaction networks underlying physiological and developmental processes. Here we supply a brief description of its basic concepts and introduce some useful tools for systems and developmental biologists. Along with a brief but thorough theoretical primer, we demonstrate the wide applicability and biological application-specific nuances by way of different illustrative vignettes. In particular, we focus on the characterisation of biological information processing efficiency, examining cell-fate decision making processes, gene regulatory network reconstruction, and efficient signal transduction experimental design.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 35, November 2014, Pages 98-108
Journal: Seminars in Cell & Developmental Biology - Volume 35, November 2014, Pages 98-108
نویسندگان
Siobhan S. Mc Mahon, Aaron Sim, Sarah Filippi, Robert Johnson, Juliane Liepe, Dominic Smith, Michael P.H. Stumpf,