کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480592 1551387 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational and mathematical methods for morphogenetic gradient analysis, boundary formation and axonal targeting
ترجمه فارسی عنوان
روش های محاسباتی و ریاضی برای تحلیل شیب مورفوژنیک، شکل گیری مرز و هدف گیری آکسون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Morphogenesis and axonal targeting are key processes during development that depend on complex interactions at molecular, cellular and tissue level. Mathematical modeling is essential to bridge this multi-scale gap in order to understand how the emergence of large structures is controlled at molecular level by interactions between various signaling pathways. We summarize mathematical modeling and computational methods for time evolution and precision of morphogenetic gradient formation. We discuss tissue patterning and the formation of borders between regions labeled by different morphogens. Finally, we review models and algorithms that reveal the interplay between morphogenetic gradients and patterned activity for axonal pathfinding and the generation of the retinotopic map in the visual system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 35, November 2014, Pages 189-202
نویسندگان
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