کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480630 1551389 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sexual modulation of neural circuits and behavior in Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Sexual modulation of neural circuits and behavior in Caenorhabditis elegans
چکیده انگلیسی
Sex differences in behavior-both sex-specific and shared behaviors-are fundamental to nearly all animal species. One often overlooked mechanism by which these behavioral differences can be generated is through sex-specific modulation of shared circuitry (i.e., circuits present in both sexes). In vertebrates this modulation is likely regulated by hormone-dependent mechanisms as well as by somatic sex itself; invertebrate models have particular promise for understanding the latter of these. Here we review molecular and behavioral evidence of sexual modulation of shared circuitry in the nematode Caenorhabditis elegans. Multiple behaviors in this species, both copulatory and not, are modulated by the genetic sex of shared neurons and circuit. These studies are close to uncovering the molecular mechanisms by which somatic sex modulates neural function in the worm, mechanisms which may be well conserved in more complex organisms. Improving our understanding of the modulation of neural circuit development and function by somatic sex may lend important insight into sex differences in the mammalian nervous system which, in turn, may have important implications for sex biases in disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 33, September 2014, Pages 3-9
نویسندگان
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