کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480670 1551390 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TGFβ signaling in establishing left-right asymmetry
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
TGFβ signaling in establishing left-right asymmetry
چکیده انگلیسی
Two TGFβ-related proteins, Nodal and Lefty, are asymmetrically expressed and play central roles in establishing left-right (L-R) asymmetry of our body. Nodal acts as a left-side determinant whereas Lefty restricts Nodal activity to the left side by acting as a feedback inhibitor of Nodal. While the mechanism for symmetry breaking is variable among animals, the pair of Nodal and Lefty has a conserved role in the L-R asymmetry pathway. Function and regulation of Nodal and Lefty have been revealed in the last decades, but in this review we summarize the role of TGFβ-related proteins together with more recent findings. We mainly discuss observations made with mouse embryos, unless indicated otherwise.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 32, August 2014, Pages 80-84
نویسندگان
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