کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8502199 | 1553967 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genome-wide association study identifies three loci for intramuscular fat in Hanwoo (Korean cattle)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
This study identified 59 SNPs significantly (P<0.001) associated with IMF using a genome-wide SNP panel, validating three SNPs using a validation dataset. The largest numbers (9 SNPs, 15% of the total significantly associated SNPs) of SNPs significantly associated with IMF were in BTA1. Of these, five were located between BTA1:22-27Â Mb and three were between BTA1:82-85Â Mb. The significantly associated SNPs accounted for only 3-5% of additive genetic variance. In the validation dataset, 3 SNPs (Hapmap54608-rs29020417, ARS-BFGL-NGS-5976 and Hapmap47624-BTA-44484) that showed an association with IMF in the single-point GWAS were significantly, positively associated with percent IMF (favorable alleles). One SNP (ARS-BFGL-NGS-29493) was significantly negatively associated (unfavorable allele). This study found that, in Hanwoo cattle, three loci were associated with IMF using GWAS and a validation dataset. The 3 SNPs explain 5.4% of phenotypic variation for IMF in Hanwoo commercial steers. In conclusion, IMF had a high heritability (0.5) but was expected to be affected by many loci with small effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Livestock Science - Volume 165, July 2014, Pages 27-32
Journal: Livestock Science - Volume 165, July 2014, Pages 27-32
نویسندگان
S.H. Lee, B.H. Choi, S.H. Cho, D. Lim, T.J. Choi, B.H. Park, J.H. Lee, C. Gondro, A. Sharma, C.G. Dang, S.S. Jang, H.K. Lee, H.S. Kang, B.S. Yang,