کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8505062 1555215 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma
ترجمه فارسی عنوان
تجزیه و تحلیل جامع از پروفایل های بیان ژن، نامزدهای جدیدی از عوامل مقاوم در برابر شیمی در لنفوم سگ را نشان می دهد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 228, October 2017, Pages 18-21
نویسندگان
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