کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8509024 | 1556008 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TLC-densitometric and first derivative spectrophotometric methods for determination of cefoxitin-sodium in presence of its alkali-induced degradation product
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Two simple and accurate methods were developed for quantitative estimation of cefoxitin sodium in presence of its open ring alkali-induced degradation product. The first method was based on TLC separation of the drug from its alkali-induced degradation product followed by densitometric measurement of the intact drug at 254 nm. The proposed method obeys Beer's law in range (1-20 µg/band). The second method was first derivative (1D) spectrophotometric method; was based on measurement of amplitude of first order spectra of cefoxitin sodium (in the range of 4-36 µg mLâ1) at 282 nm which showed zero crossing point of its degradation product. The two methods were validated according to ICH guideline for accuracy, precision and were successfully applied for the determination of the drug in pure form and pharmaceutical preparation in presence of its alkali-induced degradation product.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 55, Issue 2, December 2017, Pages 281-286
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 55, Issue 2, December 2017, Pages 281-286
نویسندگان
Khalid Abdel-Salam M. Attia, Omar Abdel-Aziz, Nancy Magdy, Ghada F. Mohamed,