کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8509316 | 1556010 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The potential effects of Melicope ptelefolia root extract as an anti-nociceptive and anti-inflammatory on animal models
ترجمه فارسی عنوان
اثرات بالقوه عصاره ریشه پلتفولیا ملکوپ به عنوان یک ضد التهاب و ضد التهابی در مدل های حیوانی
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کلمات کلیدی
ضد درد، پرنده گردن، ادم، درد،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The demand of herbal medicine has been increasing for the purpose of reducing the side effects of modern medicine. Melicope ptelefolia (M. ptelefolia) is a local Malaysian plant claimed to have many benefits for health. This study was performed to evaluate the potential of M. ptelefolia root extract as anti-nociceptive and anti-inflammatory agents in rats. The anti-nociceptive activity of M. ptelefolia root extracts (50 and 100 mg/kg) was evaluated using acetic acid-induced writhing and tail immersion test, while the anti-inflammatory activity was studied using carrageenan-induced paw edema test. M. ptelefolia root extract significantly inhibited the pain stimulant in acetic acid-induced writhing test, however it did not exert any significant change in the tail immersion test. Nevertheless, the mean reaction time in tail immersion test of M. ptelefolia root extract increased as the doses of extract increased. Furthermore, M. ptelefolia root extract at both doses showed significant anti-inflammatory activity by reducing paw edema volume (p < 0.05). In conclusion, methanol root extract of M. ptelefolia possesses anti-inflammatory effects and anti-nociceptive effects in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 54, Issue 2, December 2016, Pages 237-241
Journal: Bulletin of Faculty of Pharmacy, Cairo University - Volume 54, Issue 2, December 2016, Pages 237-241
نویسندگان
Mahani Mahadi, Nadra Abdul Rahman, Deebaneesan Viswanathan, Izatus Shima Taib, Adnan Sulong, Waheedah Abdul Hakeem, Masro Mohamad, Imtiaz Khalid Mohammed, Ismin Izwani Zainol Abidin, Shamima Abdul Rahman, Zauyah Yusuf,