کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8512644 | 1556458 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel oral administrated ellagic acid nanoparticles for enhancing oral bioavailability and anti-inflammatory efficacy
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Ellagic acid (EA), a naturally occurring polyphenolic compound, is commonly known for its anti-inflammatory properties. The low bioavailability greatly limits the clinical applications of EA. In this study, a biodegradable hollow zein nanoparticle with an average diameter of about 70â¯nm was developed to mediate oral delivery of EA. The inner core of the nanoparticle consists of EA/sodium carbonate (EA/Na2CO3) prepared by coprecipitation, which was further encapsulated in hollow zein nanoparticles with triethyl citrate as a natural plasticizer. The optimized ellagic acid-hollow plasticized zein nanoparticles (EA-HTZN) exhibited a small dimension of 72â¯nm with a PDI of 0.131, a drug loading capacity as high as 326â¯â¯mgâ¯gâ1 at an equilibrium concentration of 5.0â¯â¯mgâ¯mLâ1. EA-HTZN had high drug loading and prevented their precipitation at simulated physiological environment. The EA-HTZN significantly improved permeation ability in vitro. Oral administration of EA-HTZN showed effective against inflammation related to suppression of pro-inflammatory cytokines (TNFα, IL1 β) overproduction in carrageenan-induced mouse paw edema model. Pharmacokinetic parameters of optimized formulation revealed 3.6- and 2.1-fold increase in bioavailability as compared to EA suspension and EA solid nanoparticle, respectively. Together, these results demonstrated the successful formulation of EA-HTZN and their potential to improve oral delivery through high drug loadings and good stability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 46, August 2018, Pages 215-222
Journal: Journal of Drug Delivery Science and Technology - Volume 46, August 2018, Pages 215-222
نویسندگان
Jinghua Ruan, Ying Yang, Fumei Yang, Ke Wan, Dongsheng Fan, Daoping Wang,