کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8512932 | 1556481 | 2018 | 48 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-Helicobacter pylori effect of various extracts of ixeris chinensis on inflammatory markers in human gastric epithelial AGS cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anti-Helicobacter pylori effect of various extracts of ixeris chinensis on inflammatory markers in human gastric epithelial AGS cells Anti-Helicobacter pylori effect of various extracts of ixeris chinensis on inflammatory markers in human gastric epithelial AGS cells](/preview/png/8512932.png)
چکیده انگلیسی
Ixeris chinensis (Thunb.) Nakai (Taiwan) is a traditional herbal medicine used for treating various ailments, such as stomach ache, common cold and diarrhoea. The objective of the present study was to evaluate the antioxidative, anti-inflammatory and anti-adhesive effect of I. chinensis on Helicobacter pylori (H. pylori)-induced gastric adenocarcinoma in an AGS cell model. Three types of I. chinensis extract were used: boiling water extract (BWE), ethanol extract (EE) and chloroform extract (CE) to check anti-H. pylori activity on the AGS cell line. Phytochemical and HPLC analysis were performed. In vitro antioxidant activity, including TEAC, DPPH and H2O2 scavenging abilities, was evaluated. In addition, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined, and an MTT assay determined survival rate. Furthermore, interleukin-8 (IL-8), tumor necrosis factor (TNF-α) and nitric oxide (NO) levels were measured. The BWE showed better antioxidative activity than the EE and CE. The lag time of human low-density lipoprotein (LDL) oxidation was significantly increased by BWE, EE and CE. However, CE showed maximum antibacterial (MIC, MBC), anti-adhesive (urease test) and anti-inflammatory (IL-8, NO, TNF-α) activities. Based on the above findings, I. chinensis extract (BWE and CE) clearly shows antioxidative, anti-inflammatory and anti-adhesive effects on H. pylori-induced gastric adenocarcinoma in the AGS cell model. Hence, I. chinensis might be used to combat against H. pylori-induced gastric cancer with standard chemotherapeutic agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Herbal Medicine - Volume 11, March 2018, Pages 60-70
Journal: Journal of Herbal Medicine - Volume 11, March 2018, Pages 60-70
نویسندگان
Min-Chi Lu, Hui-Fang Chiu, Chih-Ping Lin, You-Cheng Shen, Kamesh Venkatakrishnan, Chin-Kun Wang,