کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
8515917 1556532 2018 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
The role of trophoblastic epigenetic reprogrammation in benign tumor cells on malignant progression: A molecular hypothesis
ترجمه فارسی عنوان
نقش برنامه ریزی اپیزیونیک تروفوبلاستیک در سلول های خوش خیم تومور در پیشرفت بدخیم: یک فرضیه مولکولی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
Cancer tissues and placental ones share many properties such as invasiveness, metastasis and local immunosuppressive effects. The goal of the present article is to hypothesize a theory about cancer origin that links placental and cancerous tissues at molecular level. This hypothesis explain that cancer origin could be due to low hypoxic conditions in the peripheral zones of benign tumors which might up-regulate the expression of IGF2, and, consequently, trophoblastic genes. In fact, many phenotypic characteristics and molecular markers are shared between these two cell types (cancerous and trophoblastics ones), providing evidences to support this hypothesis. As a consequence, it could be interesting to demonstrate whether cancer start with a cellular reprogrammation towards a trophoblastic fate in order to design new antitumoral strategies focused on this fact.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 113, April 2018, Pages 68-71
نویسندگان
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