کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8515994 1556534 2018 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Understanding pluripotency under folic acid deficiency using embryonic stem cells as an in vitro model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Understanding pluripotency under folic acid deficiency using embryonic stem cells as an in vitro model
چکیده انگلیسی
Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or indirectly, with DNA and Histone methylation, One carbon metabolism has an important role to play as far as epigenetic regulation of stemness is concerned. Folic acid being a methyl donor, forms an important component of One Carbon metabolism, and thus its availability has a significant effect on the methylation reactions. The present hypothesis says, using embryonic stem cells grown in vitro as a model system, one can study how deficiency of Folate during pre implantation embryonic development influence the self renewal as well as pluripotency of stem cells, from the perspective of One carbon metabolism and epigenetic mechanisms. Findings from such a study can possibly provide an explanation for the observed intra uterine growth retardation seen under maternal micronutrient deficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 111, February 2018, Pages 24-26
نویسندگان
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