Promising horizon to alleviate Alzeheimer's disease pathological hallmarks via inhibiting mTOR signaling pathway: A new application for a commonplace analgesic

Putting all the pieces of experimental evidence together, we hypothesize that tramadol might alleviate AD pathological hallmarks at least in cellular level through decreasing activity of PI3K-AKT and ERK and also mTOR signaling pathways respectively and results in autophagy activation as well as tau-dephosphorylation.