کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8526877 | 1557987 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two new sesquiterpenes, trivially named ricinusoids A (1) and ricinusoids B (2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D- and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds (1â2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kgâ1 i.p. Pretreatment of both test compounds caused significant (P ⤠0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds (1â2) possessed marked sedative and antinociceptive effects in animal models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 16, Issue 3, March 2018, Pages 225-230
Journal: Chinese Journal of Natural Medicines - Volume 16, Issue 3, March 2018, Pages 225-230
نویسندگان
Umar Farooq, Ajmal Khan, Sadia Naz, Abdur Rauf, Haroon Khan, Afsar Khan, Irfan Ullah, Syed Majid Bukhari,