کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8526894 | 1557987 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents
ترجمه فارسی عنوان
کشف مشتقات جدید لیمونین به عنوان عوامل ضد التهابی و ضد درد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
مشتقات لیمونین، ضد درد، ضد التهابی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
چکیده انگلیسی
Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 16, Issue 3, March 2018, Pages 231-240
Journal: Chinese Journal of Natural Medicines - Volume 16, Issue 3, March 2018, Pages 231-240
نویسندگان
Shao-Chi WANG, Yun YANG, Jing LIU, Ai-Dou JIANG, Zhao-Xing CHU, Si-Ying CHEN, Guo-Qing GONG, Guang-Wei HE, Yun-Gen XU, Qi-Hua ZHU,