کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8527555 | 1558000 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacology of mangostins and their derivatives: A comprehensive review
ترجمه فارسی عنوان
فارماکولوژی مگنوزین ها و مشتقات آنها: یک بررسی جامع
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کلمات کلیدی
منگستین، مشتقات، فعالیت های دارویی، فارماکوکینتیک، سم شناسی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
چکیده انگلیسی
Mangosteen (Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit's pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer's disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs). Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies of mangostins are also described for further druggability exploration in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 15, Issue 2, February 2017, Pages 81-93
Journal: Chinese Journal of Natural Medicines - Volume 15, Issue 2, February 2017, Pages 81-93
نویسندگان
Ming-Hui WANG, Kuo-Jun ZHANG, Qin-Lan GU, Xiao-Ling BI, Jin-Xin WANG,