کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8529048 | 1558851 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models](/preview/png/8529048.png)
چکیده انگلیسی
Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. Clinically, ADS resembles a classical drug withdrawal syndrome, albeit differing from it because antidepressants generally do not induce addiction. The growing clinical importance and prevalence of ADS necessitate novel experimental (animal) models of this disorder. Currently available preclinical models of ADS are mainly rodent-based, and study mostly serotonergic antidepressants and their combinations. Here, we systematically assess clinical ADS symptoms and discuss current trends and challenges in the field of experimental (animal) models of ADS. We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and emphasize how using animal models may help generate important translational insights into human ADS condition, its prevention and therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 829, 15 June 2018, Pages 129-140
Journal: European Journal of Pharmacology - Volume 829, 15 June 2018, Pages 129-140
نویسندگان
Konstantin N. Zabegalov, Tatiana O. Kolesnikova, Sergey L. Khatsko, Andrey D. Volgin, Oleg A. Yakovlev, Tamara G. Amstislavskaya, Polina A. Alekseeva, Darya A. Meshalkina, Ashton J. Friend, Wandong Bao, Konstantin A. Demin, Raul R. Gainetdinov,