کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8529051 | 1558850 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition](/preview/png/8529051.png)
چکیده انگلیسی
Steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to control inflammatory pain, but there is a risk of gastrointestinal bleeding and increased heart failure risk. The search for new drugs remains ongoing, and natural products are a source for potential new compounds. Mangiferin, a natural xanthone C-glucoside, has demonstrated biological activity, including anti-inflammatory and analgesic properties, but it's mechanisms are poorly understood. In this study, we investigated the mechanisms underlying the anti-inflammatory and analgesic effects of local administration of mangiferin. We employed an electronic von Frey apparatus to evaluate mechanical hyperalgesia induced by carrageenan in rats. Mangiferin (150-1200â¯Âµg/paw), administered locally into the hindpaw, prevented hyperalgesia in a dose-dependent - 150â¯Âµg (â 9%), 300â¯Âµg (â 27%, Pâ¯<â¯0.01), 600â¯Âµg (â 77%, Pâ¯<â¯0.001) and 1000â¯Âµg (â 93%, Pâ¯<â¯0.001) - and local manner. Mangiferin showed decreased levels of TNF-α (Pâ¯<â¯0.001) and CINC-1 (Pâ¯<â¯0.001), but not IL-1β; it also prevented neutrophil migration (Pâ¯<â¯0.01), but not the increased COX-2 expression in peripheral tissue challenged with carrageenan. To further explore the mechanisms of mangiferin actions, rats were injected with modulators of inflammation and nociception; mangiferin prevented hyperalgesia induced by IL-1β (Pâ¯<â¯0.01), CINC-1 (Pâ¯<â¯0.01), epinephrine (Pâ¯<â¯0.01), 8-Br-cAMP (Pâ¯<â¯0.01) or capsaicin (Pâ¯<â¯0.01), but not that induced by PGE2 or α,β-MeATP. Our study shows that mangiferin has anti-inflammatory and analgesic properties when locally administrated. The control of the inflammatory response and mechanical hyperalgesia by mangiferin depends on the inhibition of TNF-α production/release and the CINC1/epinephrine/PKA pathway, supporting its marked inhibition of inflammatory mechanical hyperalgesia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 830, 5 July 2018, Pages 87-94
Journal: European Journal of Pharmacology - Volume 830, 5 July 2018, Pages 87-94
نویسندگان
Lilian Wünsch Rocha, Ivan José Magayewski Bonet, Claudia Herrera Tambeli, Felipe Meira de-Faria, Carlos Amilcar Parada,