Heterocyclic pyrrolizinone and indolizinones derived from natural lactam as potential antifungal agents

Two series of multi-substituted pyrrolizinone and indolizinone derivatives based on natural cyclic ketone-enol scaffold were designed, synthesized and evaluated for their potential antifungal activities against six species of the plant pathogen fungi (Fusarium graminearum, Sclerotinia sclerotiorum, Phomopsis adianticola, Gloeosporium theae-sinensis, Alternaria tenuis Nees, Magnaporthe oryzae). The results indicated that compounds 7l and 7t displayed obviously inhibition activities against Phomopsis adianticola compared to the hymexazol.350