Liquisolid Technique Based Sustained Release Tablet of Trimetazidine Dihydrochloride

This investigation provided evidence that Polysorbate-80 (Tween 80) has important role in sustaining the release of drug from liquisolid matrices. The dissolution profile followed the Higuchi and Peppas model, shows near zero order release for prolonged period. The FT-IR spectra revealed that there is no interaction between drug-excipients used; there is no significant difference in the mean percentage of drug released from formulation E3 after storing for 6 months at 40 ± 2 °C/75 ± 25% RH, after 12 h. The amount of TZH released from marketed formulation (MR) and Liquisolid matrices (E3), showed a significant difference statistically (ANOVA P < 0.05).