Studies on cerebroprotective potential of 2,4,6-trisubstituted-1,3,5-pyrimidines in global ischemia/reperfusion induced cerebral infarction in rats

A dose dependent cerebroprotective action of pyrimidines (AUCP1 and AUCP2) in terms of limiting the infarct size was observed in the present in vivo model of cerebral I/R in Wistar rats. The antioxidant role of pyrimidines (AUCP1 and AUCP2) in cerebroprotection was confirmed by measuring SOD, CAT, MDA, levels. MDA levels were decreased; SOD and CAT levels were increased by treatment with pyrimidines (AUCP1 and AUCP2). The cerebroprotective actions of pyrimidines (AUCP1 and AUCP2) are partially attributed to their anti-inflammatory effects against I/R injury in rats as evidenced by significant reduction in pro-inflammatory markers MPO, TNF-α and significant increase in anti-inflammatory marker IL-10. Pyrimidines (AUCP1 and AUCP2) evaluated in the present investigation has offered significant cerebroprotection against ischemia-reperfusion induced cerebral infarction in rats.