Design of lamivudine XR matrix tablets: Influence of HPMC and PEO on in vitro drug release and bioavailability in rabbits

The release of the matrix tablets for prolonged periods of time employing polyethylene oxide and hydroxypropyl methylcellulose as drug rate retarding polymers could be advantageous than conventional lamivudine tablets. The study could be extended for bioavailability studies in clinical subjects.