In vitro brain GABA-transaminase activity of 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione derivatives

In conclusion, 1-(4-acetylphenyl)-3-(4-Bromophenyloxy)-pyrrolidine-2,5-dione 5d and 1-(4-acetylphenyl)-3-(Salicyldehydoxy)-pyrrolidine-2,5-dione 5h strongly fulfill where as 1-(4-acetylphenyl)-3-(2,4,6-Nitrophenyloxy)-pyrrolidine-2,5-dione 5l and 1-(4-acetylphenyl)-3-(2-Napthyloxy)-pyrrolidine-2,5-dione 5b significantly fulfill the criteria for mice brain GABA-T inhibitory agents.