کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8542612 | 1561450 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidiabetic effect of methanolic extract of Decalepis hamiltonii root (wight and Arn) in normal and alloxan induced diabetic rats
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
فارماکولوژی، سم شناسی و اقلام دارویی (عمومی)
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چکیده انگلیسی
Diabetes mellitus is a major health growing problem in most countries. Purpose of the study was to evaluate the antidiabetic activity of methanolic extracts of root of Decalepis hamiltonii in normal and alloxan induced diabetic rats. Alloxan monohydrate 120Â mg/kg was used to induce diabetes mellitus. The methanolic extract of D. hamiltonii at 200Â mg and 400Â mg and glibenclamide at 7Â mg/kg bwt were administered to normal and alloxan induced diabetic rats which significantly reduced the blood glucose in the normal rats and alloxan induced diabetic rats. Also the administration of extract significantly decreased serum total cholesterol, triglyceride, and AST and ALT levels and at the same time increased liver glycogen content. OGTT was performed by administration of 200Â mg and 400Â mg of methanolic extract of D. hamiltonii and 7Â mg of glibenclamide to different groups respectively which significantly lower at all time points that blood was sampled after oral glucose load. These results suggest that the methanolic extract of root of D. hamiltonii was effective in lowering blood glucose level in diabetic rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacy Research - Volume 6, Issue 1, January 2013, Pages 166-172
Journal: Journal of Pharmacy Research - Volume 6, Issue 1, January 2013, Pages 166-172
نویسندگان
Devi Manickam, Latha Periyasamy,