Amlexanox in treatment of aphthous ulcers: A systematic review

Aphthous ulcers (Canker sores) are recurrent multiple ulcers occurring in oral mucosa mainly in the buccal mucosa, labial mucosa, floor of the mouth and tongue. The etiology for aphthous is still not clear though many predisposing factors like stress, trauma, immunologically mediated, infectious agents like virus etc., are considered. As the etiopathogenesis of the disease is multifactorial, treatment mainly aims in symptomatic management of pain or burning sensation using mainly topical anesthetics or antiseptics. To facilitate the healing process, various anti-inflammatory and anti-allergic agents are also tried. A medication which could help in reduction of pain, ulcer size, erythema, ulcer duration and prevent recurrence is essential to treat the ulcers. The efficacy of Amlexanox in treatment of aphthous ulcers is tried in various clinical trials. This systematic review article aims in evaluation of Amlexanox efficacy in satisfying all the demands such as reduction of pain, ulcer size, ulcer duration erythema and recurrence.