Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells

- Digiferrol is a novel activator of the p53 pathway.
- Digiferrol stabilizes p53 protein in the nucleus.
- Digiferrol induces cell cycle arrest at G2/M phase in colon cancer cells.
- Digiferrol promotes apoptosis and autophagy in colon cancer cells.