کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8547212 | 1561729 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proteomic effects of repeated-dose oral exposure to 2-monochloropropanediol and its dipalmitate in rat testes
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کلمات کلیدی
EFSAIPA3-MCPDToxicoproteomicsMCPD2-MCPDMAPK - MAPKEuropean Food Safety Authority - اداره ایمنی اروپاIngenuity Pathway Analysis - تجزیه و تحلیل راه Ingenuitymatrix-assisted laser desorption/ionization - جذب / یونیزاسیون لیزر ماتریس کمک می کندMALDI - مالدیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Proteomic effects of repeated-dose oral exposure to 2-monochloropropanediol and its dipalmitate in rat testes Proteomic effects of repeated-dose oral exposure to 2-monochloropropanediol and its dipalmitate in rat testes](/preview/png/8547212.png)
چکیده انگلیسی
2- and 3-monochloropropanediol (2-MCPD) and their fatty acid esters are food contaminants which are concomitantly formed upon thermal treatment of foodstuff containing fats and salt. Exposure to 2- or 3-MCPD thus results, for example, from refined vegetable oils, in instant meals or infant formula, as well as in cereals or pastries. The molecular mechanisms of 2-MCPD toxicity are poorly understood. Here, we performed a comprehensive proteomic analysis of 2-MCDP-induced alterations in the testes from rats following oral administration of 10â¯mg/kg body weight per day 2-MCPD, or an equimolar dose of 2-MCPD dipalmitate as a representative 2-MCPD fatty acid ester. In the absence of overt histopathologically detectable toxicity, moderate alterations in cellular proteomic signatures were recorded. The observations are in line with the assumption that the molecular mechanisms of 2-MCPD and 3-MCPD toxicity differ. Observed proteomic alterations point towards effects of 2-MCPD on mitogen-dependent signaling and mitochondrial energy utilization. Presented data for the first time provide insight into proteomic effects of 2-MCPD in testicular tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 116, Part B, June 2018, Pages 354-359
Journal: Food and Chemical Toxicology - Volume 116, Part B, June 2018, Pages 354-359
نویسندگان
Falko Frenzel, Axel Oberemm, Alfonso Lampen, Albert Braeuning,